histone deacetylase

Objective: To explore the effect of histone deacetylase inhibitors on the excretion levels of IL-10 and IL-12 in patients with SLE.

目的：探讨组蛋白去乙酰化酶（HDAC）抑制剂对系统性红斑狼疮（SLE）患者外周血全血培养细胞中IL-10和IL-12分泌水平的影响。

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Construction of the conserved histidine residue mutations of histone deacetylase 1

组蛋白脱乙酰化酶-1保守氨基酸中组氨酸定点突变的建立

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FK228 with a special depsipeptide may efficiently pass through the cellular membrane and exert a prominent anti-tumor activity by inhibiting histone deacetylase.

FK228具有特殊的缩酯环肽结构，可有效透过细胞膜，通过抑制组蛋白去乙酰酶而显示良好的抗肿瘤活性。

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The re-expression of p15~ ( INK4B) gene in leukemia cells induced by in vitro DNA methyltransferase and histone deacetylase inhibition

体外试验诱导白血病细胞p15~（INK4B）基因重新表达

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Dynamic Changes of Histone Deacetylase 1 during Regulated Growth of Bronchial Stem Cells in Human Bronchial Regeneration

组蛋白去乙酰化酶1在气管干细胞增殖分化过程中的时空表达

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These results indicate that although histone deacetylase can be served as a potential target for treating AD, continuous drug administration may be required.

这些结果显示，即使组蛋白去乙酰化酶可以作为治疗AD的潜在靶点，但是持续的用药还是必需的。

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With intensive study, the mechanism of histone deacetylase inhibitors in leukemia has been paid more and more attention.

随着对组蛋白乙酰化的深入研究，组蛋白去乙酰化酶抑制剂在白血病中的作用机制越来越受到人们的关注。

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Deacetylation of p53 is the contrary process of acetylation of p53, which is mediated by histone deacetylase ( HDACs).

p53去乙酰化是与乙酰化相反的过程，由组氨酸去乙酰化酶介导。

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Enhancive Effect of Histone Deacetylase Inhibitor Trichostatin A on Transfection Efficiency of Adenovirus in Ovarian Carcinoma Cell Line A2780

HDAC抑制剂TSA增强卵巢癌细胞株A2780对腺病毒基因转染效率的体外研究

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Effect of phenylbutyrate, a histone deacetylase inhibitor, on differentiation and apoptosis of Kasumi-1 cells

脱乙酰化酶抑制剂苯丁酸钠体外诱导Kasumi1细胞分化和凋亡作用

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Therefore, this study aims to investigate the effect of histone deacetylase inhibitors on porcine granulosa cells and its preliminary mechanism. All the results can provide a reference for clinical use.

因此，本试验以TSA为代表药物，研究组蛋白去乙酰化酶抑制剂对猪卵巢颗粒细胞的作用，并就其机理作初步探讨，以为临床用药提供一定的参考。

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The Expression of Histone Deacetylase 2 in Hypertrophic Cardiocytes

心肌细胞肥大过程中组蛋白脱乙酰基酶2的表达

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Expression of histone deacetylase 2 in hypertrophic cardiocytes induced by angiotensin ⅱ

组蛋白脱乙酰基酶2在血管紧张素Ⅱ致心肌细胞肥大中的表达

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The pharmacological actions of histone deacetylase inhibitors and their potential clinical uses were reviewed.

综述了组蛋白去乙酰酶抑制剂的药理作用及其临床应用前景。

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Expression of Histone Deacetylase 1 in Human Lung Cancer

组蛋白去乙酰化酶1在人肺癌组织中的表达

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Histone deacetylase is protein that can influence the cell cycle, differentiation and apoptosis through the modification of acetyl level of histones.

组蛋白去乙酰化酶是一类通过调节组蛋白乙酰化的程度来影响细胞周期、分化和凋亡的蛋白。

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Objective: To improve the synthetic procedure of the histone deacetylase ( HDAC) inhibitor SAHA.

目的：改进组蛋白去乙酰化酶抑制剂SAHA的合成工艺。

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The inhibition of the histone deacetylase enzymes induces hyperacetylation of the histone proteins.

组蛋白脱乙酰酶的抑制引起了组蛋白的高乙酰化。

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Background: Histone deacetylase inhibitor ( HDACi) is a promising class of anticancer agents with high efficiency on inhibiting tumor growth, inducing cell differentiation and/ or apoptosis.

研究背景：组蛋白去乙酰化酶抑制剂（HDACi）是一类能够有效抑制抑制肿瘤细胞增殖、诱导细胞分化、促进细胞凋亡的抗肿瘤新药。

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Molecular mechanism of p21~ ( WAF1/ CIP1) expression induced by histone deacetylase inhibitors in HeLa cell line

组蛋白去乙酰化酶抑制剂诱导HeLa细胞p21~（WAF1/CIP1）表达的分子机制研究

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Histone Deacetylase Maybe Involved in the Mechanism of Inhibition of Tyrosine Hydroxylase Expression in α-Synuclein-Transfected Dopaminergic Neuronal Cells

组蛋白脱乙酰化酶在α-突触核蛋白抑制酪氨酸羟化酶表达中的作用

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Experimental study in vitro on histone deacetylase inhibitor MS-275 inhibiting bladder cancer

组蛋白去乙酰酶抑制剂MS-275抑制膀胱癌的实验研究

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Role of Histone Deacetylase 1 in Human Lung Adenocarcinoma Carcinogenesis

组蛋白去乙酰化酶1在肺腺癌发生发展中的作用

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Over the last decade, histone deacetylase inhibitors attracted considerable attention due to its important role in the regulation of histone acetylation and deacetylation from normal and cancer cell.

最近十年，组蛋白去乙酰化酶抑制剂因调节正常细胞和癌细胞中组蛋白乙酰化和去乙酰化水平的重要作用而受到广泛的关注。

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The paper proposed a possible binding mode of MS-275, a benzamide histone deacetylase ( HDAC) inhibitor, to HDAC by intensive docking study.

通过计算机模拟的对接过程研究，发现了MS-275&一种苯甲酰胺类的组蛋白去乙酰酶（HDAC）抑制剂与酶的可能的全新结合方式。

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Histone deacetylase ( HDAC) greatly affects the chromatin topology and gene expression, and HDAC can be a new strategy in human cancer or tumour therapy.

组蛋白去乙酰化酶（HDAC）对染色质分布和基因调节起着重要的作用，也是治疗癌症和其它疾病的新靶点。

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Effect of Inhibitors for Demethylation and Histone Deacetylase on Proliferation of Cell Line K562 and Expression of Tumor Related Genes

去甲基化和组蛋白去乙酰化转移酶抑制剂对K562细胞增殖和肿瘤相关基因表达的影响

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Role of histone deacetylase 6 in aggresome and neurodegenerative diseases

组蛋白脱乙酰基酶6在聚集小体和神经变性疾病中的作用

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Effects of DNA Demethylation and Histone Deacetylase Inhibition to Estrogen Receptor of Prostate Cancer Cell-Lines

去甲基化抑制剂和组蛋白去乙酰化转移酶抑制剂对前列腺癌细胞株雌激素受体的影响

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Relationship Between Systemic Inflammation and Activity of Histone Deacetylase in Peripheral Blood Mononuclear Cells from COPD Patients

慢性阻塞性肺病外周血单个核细胞中的组蛋白去乙酰化酶活性与全身炎症的关系

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